• Hakai overexpression effectively induces tumour progression and metastasis in vivo.
    Castosa, R., Martinez-Iglesias, O., Roca-Lema, D., Casas-Pais, A., Diaz-Diaz, Iglesias, P., Santamarina, I., Graña, B., Calvo, L., Valladares-Ayerbes, M., Concha, C. and Figueroa, A. Sci. Reports (2018) 8: 3466.
  • Diaz-Diaz, A., Casas-Pais, A., Castosa, R., Calamia, V., Martinez-Iglesias, O., Roca-Lema, D., Santamarina, I., Valladares-Ayerbes, M., Calvo, L., Chantada, V., Figueroa, A. Proteomic analysis of the E3 ubiquitin-ligase Hakai highlights a role in plasticity of the cytoskeleton dynamics and in the proteasome system. J  Proteome Res. (2017) 16: 2773-2788.
  • Aparicio, LA.* Blanco, M.*,  Castosa, R.,  Concha, A., Valladares, M., Calvo, L and Figueroa, A. Clinical Implications of epithelial cell plasticity in cancer progression. Cancer Letters (2015) 366:1-10. *These authors contributed equally to this work.
  • Antolín, S., Calvo, L., Blanco-Calvo, M., Santiago, MP., Lorenzo-Patiño, MJ., Haz-Conde, M., Santamarina I., Figueroa, A.,  Antón-Aparicio, LM., and  Valladares-Ayerbes, M. Circulating miR-200c and miR-141 and Outcomes in Patients with Breast Cancer. BMC Cancer (2015) 15:297.
  • Blanco-Calvo M, Concha Á, Figueroa A, Garrido F, Valladares-Ayerbes M. Colorectal Cancer Classification and Cell Heterogeneity: A Systems Oncology Approach. Int J Mol Sci. (2015)16:13610-13632.
  • Figueroa, A., Transición Epitelio-Mesénquima y Cáncer Colorrectal. Editores: Alejandro Pazos, José Luis Ulla Rocha y Manuel Valladares In: Abordaje multidisciplinar en Cáncer Colorrectal, Chapter 30.  Andavira Editora, Santiago de Compostela ISBN 978-84-8408-795-3 (2015) pp 471-483.
  • Aparicio, LA.,* Castosa, R.,* Haz, M., Rodriguez, M., Blanco, M., Valladares, M., and Figueroa, A. Role of the microtubule-targeting drug vinflunine on cell-cell adhesions in bladder epithelial tumour cells. BMC Cancer. (2014) 14:507.DOI: 10.1186/1471-2407-14-507.
  • Blanco-Calvo, M.*, Tarrío, N.*, Reboredo, M., Haz-Conde, M., García, J., Quindós, M., Figueroa, A., Antón-Aparicio,L., Calvo, L and Valladares-Ayerbes, M. Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer. Future Oncol. (2014) 10(7):1187-202.
  • Aparicio, LA., Abella V., Valladares, M., and Figueroa, A. Posttranscriptional regulation by RNA-binding proteins during epithelial-to-mesenchymal transition. Cell Mol Life Sci (2013) 70: 4463-4477.
  • Figueroa, A., Cáncer de pulmón: mecanismos moleculares y dianas terapéuticas. Editor: Verea Hernando, H. En: Investigación aplicada en Medicina Respiratoria: Un ABC para entender las innovaciones en biomedicina, Chapter 11, Andavira Editora., Santiago de Compostela ISBN 978-84-8408-724-3 (2013) pp. 163-175.
  • Abella V., Valladares, M., Rodriguez, T., Haz, M., Blanco, M., Tarrío, N., Iglesias, P., Aparicio, LA. and Figueroa, A. miR-203 regulates cell proliferation through its influence on Hakai expression. Plos One (2012) 7: e52568.
  • Aparicio LA. Valladares, M., Blanco, M., Alonso, A., Figueroa, A.  Biological influence of Hakai in cancer: 10-year review.  Can. Met. Rev. (2012) 31: 375-386.
  • Valladares-Ayerbes M, Reboredo M, Medina-Villaamil V, Iglesias-Díaz P, Lorenzo-Patiño MJ, Haz M, Santamarina I, Blanco M, Fernández-Tajes J, Quindós M, Carral A, Figueroa A, Antón-Aparicio LM, Calvo L. Circulating miR-200c as a diagnostic and prognostic biomarker for gastric cáncer. J Transl Med (2012) 10: 186.
  • Valladares-Ayerbes, M., Blanco, M., Reboredo, M.,  Lorenzo-Patiño, MJ., Iglesias-Díaz, P.,  Haz, M.,  Díaz-Prado, S., Medina, V., Santamarina, I., Pertega, S., Figueroa, A.,  Antón-Aparicio, L. Evaluation of the adenocarcinoma-associated gene AGR2 and the intestinal stem cell marker LGR5 as biomarkers in colorectal cancer Int J Mol Sci (2012) 13: 4367-4387.
  • Blanco-Calvo, M., Calvo, L., Figueroa, A., Haz-Conde, M., Antón-Aparicio, L. and Valladares-ayerbes, M. Circulating microRNAs: Molecular Microsensors in Gastrointestinal Cáncer.  Sensors (2012) 12, 9286-9299.
  • Rodriguez-Rigueiro, T., Valladares-Ayerbes, M., Haz-Conde, M., Blanco, M., Aparicio, G., Fernández-Puente, P., Blanco FJ., Lorenzo, MJ., Aparicio, LA and Figueroa A. Novel procedure for protein extraction from formalin-fixed paraffin-embedded tissues. Proteomics (2011) 11: 2555-2559.
  • Aparicio-Gallego, G.,  Blanco M., Figueroa A., Garcia-Campelo, R., Valladares-Ayerbes M., Grande-Pulido, E. and Antón-Aparicio, L. New Insights into Molecular Mechanisms of Sunitinib-Associated Side Effects. Mol. Cancer Ther. (2011) 10: 2215-2223.
  • Rodríguez-Rigueiro, T., Valladares-Ayerbes, M., Haz-Conde, M., Aparicio LA. and Figueroa, A. Hakai reduces cell-substratum adhesions and increases cell invasion in epithelial cells. BMC Cancer (2011) 11:474.
  • Valladares-Ayerbes , M., Blanco, M. , Haz, M., Medina, M., Iglesias-Díaz, P., Lorenzo-Patiño, MJ., Reboredo, R., Santamarina, I., Figueroa, A.,  Antón-Aparicio, LM. and Calvo, L.  Prognostic impact of disseminated tumor cells and microRNA-17-92 cluster deregulation in gastrointestinal cancer. Int J Oncol (2011) 39: 1253-1264.
  • Valladares-Ayerbes, M., Díaz-Pazo, S., Reboredo, M., Medina, V., Lorenzo-Patiño, MJ., Iglesias-Díaz, P., Haz, M., Santamarina, I., Calvo, MB., Quindós Varela M., Figueroa. A., and Aparicio, LA. Evaluation of Plakophilin-3 mRNA as a Biomarker for Detection of Circulating Tumor Cells in Gastrointestinal Cancer Patients. Cancer Epidemiol. Biomarkers Prev. (2010) 19: 1432-1440.
  • Calvo, MB., Figueroa, A., Grande Pulido E., Garcia Campelo R. and Aparicio LA. Potential role of sugar transporters in cancer and their relationship with anticancer therapy. Int J Endocrinol (2010) 1-14.
  • Aparicio, G., Calvo, MB., Figueroa, A.,  Valladares-Ayerbes, M. and Aparicio, LA. Generation of daughter cells in their niche. Editors: Hitomi and M. Katoaka In: Daughter cells, Chapter IV, Nova Science Publishers Inc., New York. ISBN 978-1-60876-790-8 (2010) pp. 163-196.
  • *Figueroa, A., Fujita, Y., and Gorospe, M. Hacking RNA: Hakai promotes tumorigenesis by enhancing the RNA-binding function of PSF. Cell Cycle (2009) 8: 3648-3651. (*Corresponding author)